Anesthetics in establishment of rabbit models of ileal neobladder

doi:10.3969/j.issn.2095-4344.2014.49.021

Abstract

Abstract:

BACKGROUND: The anesthesia process is required strict in establishing rabbit models of ileal neobladder. It is required for cleaning operation field, quick postoperative recovery, and the choice of anesthetics and anesthesia does not influence smooth muscle peristalsis.

OBJECTIVE: To compare the anesthetic effects between urethane and chloral hydrate in rabbits with ileal neobladder.

METHODS: Eighteen rabbits were randomly assigned to urethane and chloral hydrate groups, and were respectively anesthetized with 20% urethane 5 mL/kg and 10% chloral hydrate 2 mL/kg through the ear vein. Double ureter was dissociated at 1 cm outside original bladder, and 15 cm-intestine obtained from 10 cm of ileocecal junction was implanted so as to establish models of ileal neobladder.

RESULTS AND CONCLUSION: Heart rates were significantly lower compared with these before anesthesia in all cases (P ≤ 0.05), but no differences were detected between two groups (P > 0.05). Compared with the chloral hydrate group, the maintain time and recovery time were longer and the mortality rate was higher in the urethane group. Above data indicated that chloral hydrate is a safe long-acting anesthetic in establishing rabbit models of ileal neobladder.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

全文链接：

Key words: ileum, urinary bladder, anesthesia, anesthetics

CLC Number:

R318

Shen Jian, Huang Chun-xia, Yu Yun-lan, Liu Hong-xin, Cheng Zhi-jun. Anesthetics in establishment of rabbit models of ileal neobladder [J]. Chinese Journal of Tissue Engineering Research, 2014, 18(49): 7990-7994.

Figures/Tables 2

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